Isolation of a Receptor for Acidic and Basic Fibroblast Growth Factor from Embryonic Chick
نویسندگان
چکیده
منابع مشابه
Complete sequence of a human receptor for acidic and basic fibroblast growth factors.
Fibroblast growth factors (FGFs) are potent mitogens for several cell types, including endothelial cells. cDNA clones encoding receptors for members of the FGFs family have recently been reported (1, 2, 3). However, only a partial sequence has been published so far encoding a human receptor for acidic and basic FGF (4, 5), which was named flg. Using oligonucleotide probes derived from the flg s...
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Two putative receptors for fibroblast growth factor (FGF) of approximately 150 and 200 kD were identified in membrane preparations from chick embryos. Specific binding (femtomoles/milligram) of 125I-aFGF to whole chick embryonic membranes was relatively constant from day 2 to 7, then decreased fivefold between days 7 and 13. Day-19 chick embryos retained 125I-aFGF binding at low levels to brain...
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Basic fibroblast growth factor (bFGF) is known to bind to its cell-surface receptors with high affinity and in a heparin-dependent manner. In an attempt to predict the receptor recognition site on bFGF we screened phage-epitope libraries with monoclonal antibodies DG2 and DE6, which inhibit bFGF binding to its receptor. On the affinity-isolated phages, we identified several peptide sequences as...
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BACKGROUND/AIM Fibroadenomas are benign tumours composed of both glandular and fibrous tissue. The mechanisms regulating the growth of these tumours and the relation between the stromal and epithelial cells are poorly understood. Acidic fibroblast growth factor (aFGF) is a well known fibroblast activator, which acts through four specific cell surface receptors, among which, fibroblast growth fa...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)51516-7